Nutrient Prevents Cell Death
Cruciferous vegetables such as broccoli and Brussels sprouts have long been studied for their protective nutrients, especially in the fight against many cancers. Penn State researchers have identified a compound that may help increase sunscreens’ ability to prevent deadly melanoma formation. Isothiocyantes, the antioxidant found in cruciferous vegetables, is an inhibitor of a protein called Akt3 which plays a role in 70 percent of melanomas. Because the naturally-occurring isothiocyantes is not strong enough, researchers have developed a more potent version they call ISC-4 which could reduce tumor expansion in lab-generated skin by 80 to 90 percent and decreases tumor development in mice skin by about 80 percent.
Isothiocyanate Is Key Nutrient
Broccoli and other cruciferous vegetables have long been thought of as cancer fighting foods and researchers from the Lombardi Comprehensive Cancer Center at Georgetown University have found a specific compound that appears to stop the growth of cancer by encouraging cell death – a process known as apoptosis. Isothiocyanates, also found in cauliflower and watercress, may work by assisting a tumor suppressor gene known as p53 which helps prevent cancer growth as long as it is not mutated. Isothiocyanates will selectively bind with the mutated p53 genes to induce apoptosis, but will leave the normal version of the gene alone. Mutant p53 depletion may be an important target for cancer prevention and therapy, state the authors in the Journal of Medicinal Chemistry.
Skip the Filter
Women who drink boiled coffee versus filtered coffee four times a day may have a lower risk of developing breast cancer, according to a new study published in the journal Cancer Causes and Control. According to Lena Nilsson and colleagues at Umea University, Scandinavian boiled coffee, which is similar to French press or Turkish/Greek coffee, contains up to 80 times as much coffee-specific fatty acids that have been shown in animal studies to inhibit the growth of cancer. Among women who drank filtered coffee, there was an increased risk of early breast cancer (under 49 years old) but a lowered risk for late breast cancer (over 55 years old). Unfortunately, boiled coffee drinkers did appear to have an increased risk of pancreatic and lung cancer in men.
Cancer Fighting Duo
Scientists may be on the trail of a giant advance in the treatment of prostate cancer, and the credit goes to polyphenols in red wine and green tea. Those powerful polyphenols, which are antioxidants, inhibit cancer growth. Now, scientists understand how the process works. According to a new report published in FASEB Journal, the antioxidants in green tea and red wine create a combined effect to stop a vital cell signaling pathway that's needed for prostate cancer to grow. The discovery may improve current treatments or lead to the development of new medications to stop or slow cancer. "As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent 'health foods' we know," says Dr. Gerald Weissmann of FASEB Journal.