August 26, 2012

Shows How It May Cause Cancer

1 Study Shows Metabolite of Alcohol Damages DNA

After almost three decades of demonstrating that the risk of certain cancers are increased by alcohol consumption, results from a recent study show that acetaldehyde, the breakdown product of alcohol, binds to DNA which leads to damage that can trigger carcinogenesis. When a compound binds to DNA, it forms what is known as a DNA adduct and by giving 10 people increasing amounts of vodka for three weeks, a 100 fold increase in adducts was detected in cells from their mouth and blood after drinking. When DNA adducts form, they can interrupt replication and repair leading to mutations that can ultimately lead to cancer. Of particular concern are those of Asian descent who are deficient in the alcohol dehydrogenase enzyme that quickly converts acetaldehyde to acetate which is less harmful.

More at Science Daily | Posted 5 years ago by Kristie Hayes

Previously: 20 Possible Causes of Cancer

Tags: Acetaldehyde, Alcohol Consumption, Cancer, DNA Adducts

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