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Not a Fountain of Youth

Immune Stem Cells Age, Affects Health

Researchers at the Stanford University School of Medicine have discovered that as people age, their hematopoietic stem cells (HSC) could not differentiate into B lymphocytes as well and typically became myeloid cells by comparing HSC from 15 elderly people and 28 younger people, all of whom were healthy. The bone marrow of mice that received HSCs from human donors had more myeloid cells compared to lymphoid cells. Genes related to age that played a role in the cell cycle, growth, division, DNA repair and death of cells were upregulated which means that do not enter the cell cycle at the correct time. This may result in an elderly person’s immune system not being fully functional and explain why blood cancers such as acute myeloid leukemia are more prevalent in this age group.

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