September 12, 2011

Alzheimer’s Relationship

1 High Cholesterol Linked with Plaque in Brain

Brain changes characteristic of Alzheimer’s disease have been associated with high cholesterol levels. New research, published in Neurology, found that those with a total cholesterol of more than 224 mg/dL in middle to late life (before Alzheimer’s disease symptoms) were at least seven times more likely to have brain plaque called beta-amyloid by the time of death in comparison with people who had cholesterol under 173 mg/dL. WebMD reports that LDL cholesterol levels of more than 155 mg/dL were also associated with an increased risk of developing beta-amyloid plaques. Beta-amyloid plaques are often present in the brains of patients with Alzheimer’s disease, but it's unclear if the plaques actually cause symptoms.

More at WebMD | Posted 6 years ago by Peggy Rowland

Tags: Dangers High Cholesterol, Total Cholesterol, LDL over 155, Causes of Alzheimer’s Disease, Risks Alzheimer’s Disease

Comment on This | Was this Interesting? Yes! (45%) / No! (55%)

Increases Effectiveness

2 Combination Therapy Fights Aggressive Cancers

Experiments in mice conducted at Brigham and Women's Hospital have found that rapamycin and IPI0504 cause cancer cells in people with a tumor related to neurofibromatosis type 1 and KRAS-mutant lung cancer to regress dramatically. Both of these cancers are very hard to treat and results vary from person to person. Rapamycin works by inhibiting tumor growth and IPI-504 inhibits the activity of heat shock protein 90 (HSP 90). Individually they did not cause the tumor cells to regress in mice. These treatments are also more targeted with the goal of reducing the unwanted side effects of typical chemotherapy. Future research is going to focus on developing different drug combinations for other cancers to increase the effectiveness of treatment and ultimately the outcome.

More at Science Daily | Posted 6 years ago by Kristie Hayes

Previously: Nicotine Levels in Smoking Cessation Products Safe

Tags: Brigham and Women's Hospital, Rapamycin, Combination Chemotherapy, IPI-504, Neurofibromatosis Type 1, KRAS-Mutant Lung Cancer, Heat Shock Protein 90, HSP 90

Comment on This | Was this Interesting? Yes! (51%) / No! (49%)

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