May 15, 2011

Two Studies Make Same Conclusion

1 Genetic Link for Depression Found

Genes may cause depression, say British-led scientists who uncovered the first solid evidence of a genetic link to the mental illness. The research reveals a strong link between genetic variations in the chromosome 3p25-26 region and depression. MSNBC reports that the international study was replicated at the same time with a separate group of people in a study from Washington University. However, researchers say that it could take 10 to 15 years before patients would be offered new medications created from the research findings. Both studies were published Monday in American Journal of Psychiatry.

More at MSNBC | Posted 6 years ago by Peggy Rowland

Previously: Treating Depression in Diabetics Helps Manage Both

Tags: Major Depressive Disorder, Washington University, Depression Causes, Genetic Link Depression, Risk Factors Depression

Comment on This | Was this Interesting? Yes! (48%) / No! (52%)

Reason for Failure of Cetuximab?

2 EGFR-Targeted Cancer Drugs Bind to Decoy Receptor

Researchers at Yale School of Medicine have found that cancer drugs designed to target the epidermal growth factor receptor (EGFR) to inhibit cancer cell growth may not work because they also bind to a related receptor, serum sEGFR, with the same affinity. This may explain why the drug Cetuximab was shown to be ineffective in two phase III clinical trials involving patients with colorectal cancer and suggests people get screened for sEGFR levels to determine if they will benefit from treatment with the drug. sEGFR concentrations vary widely in people with cancer and change in those taking the drug. Reagents designed to measure blood sEGFR also measure alpha-5 integrin, present on the surface of tumor cells which leads researchers to hypothesize that sEGFR plays a role in metastasis.

More at Science Daily | Posted 6 years ago by Kristie Hayes

Previously: Blood Test for Early Detection of Breast Cancer, New Drugs Effective in Some Lung Cancer Patients

Tags: EGFR, Epidermal Growth Factor Receptor, Yale School of Medicine, Serum SEGFR, SEGFR, Alpha-5 Intergrin, Cetuximab, EGFR-Targeted Cancer Therapies

Comment on This | Was this Interesting? Yes! (46%) / No! (54%)

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