November 27, 2010

90% Effective When Taken Daily

1 AIDS Risk Reduced with One Pill a Day

There’s a new weapon in the fight against AIDS. Truvada, a combination of the antiviral drugs tenofovir and emtricitabine, was found to reduce the risk of contracting HIV. The study, conducted by the Gladstone Institutes of the University of California, included 2,499 men and showed that Truvada was 90% effective for men who took it on a daily basis. While the results are promising, some researchers and AIDS experts suggest that more tests need to be done to determine if the results can be duplicated and if it remains effective in other scenarios, such as determining the results with heterosexual men and women. The chief of the C.D.C. AIDS division, Dr. Kevin Fenton, states, “The results are encouraging, but it’s not time for gay men to throw away their condoms.”

More at New York Times | Posted 7 years ago by Marty Shaw

Previously: AIDS Drugs Cut Down on Spread of Disease

Tags: AIDS, HIV Treatment, Truvada, Tenovir, Emtricitabine

Comment on This | Was this Interesting? Yes! (39%) / No! (61%)

Inhibits Protein Tau Aggregates

2 Metformin Fights Alzheimer’s in Mice

Metformin, used to treat type 2 diabetes, fights Alzheimer’s in mouse nerve cells by preventing alterations of the protein tau. The drug works by protecting the protein PP2A, which removes phosphate groups from tau. Phosphorylation of a protein either activates or inactivates it and leads to a series of events on a molecular level. PP2A is not active enough in people with Alzheimer’s and the increased phosphorylation of the protein leads to the formation of deposits. Metformin was also put in the drinking water of healthy mice and decreased tau-phosphorylation in their brain cells. The next step is human clinical trials. Researchers already have the advantage of knowing its side effects since it is already used to treat diabetes.

More at Science Daily | Posted 7 years ago by Kristie Hayes

Previously: Alzheimer’s

Tags: Alzheimer’s, PP2A, Protein Tau, Phosphorylation of Tau, Tau Aggregates

Comment on This | Was this Interesting? Yes! (40%) / No! (60%)

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