September 29, 2010

DNA May Decide ADHD

1 ADHD May Be Genetic

Researchers believe that genetics could be responsible for attention-deficit hyperactivity disorder (ADHD), reports CNN. A new study, published in the Lancet, provides the first direct evidence that ADHD is caused by genetic abnormalities. The research, led by Dr. Nigel Williams of the Cardiff University School of Medicine in Wales, reveals that children with ADHD possess more large, rare copy-number variants (pieces of DNA that are missing or extraneous), compared to children without ADHD. The study results suggest that ADHD is a genetic disorder, but environmental factors for the disorder can't be ruled out.

More at CNN | Posted 7 years ago by Peggy Rowland

Previously: ADHD Linked to Socioeconomic Factors

Tags: ADHD Causes, Dr. Nigel Williams, Copy Number Variants, ADHD Inherited, ADHD in Genes, Genetic Basis of ADHD, Cardiff University School of Medicine, Evidence ADHD Is Real, Genetic Abnormalities

Comment on This | Was this Interesting? Yes! (43%) / No! (57%)

No More Sleepy New Docs

2 New Doctors to Work Shorter Hours

To ensure patient safety and a better learning environment for rookie doctors, the Accreditation Council for Graduate Medical Education in Chicago has approved new rules for shorter working hours for new physicians. The updated rules, affecting more than 110,000 new doctors, will take effect in July 2011, reports MSNBC. The maximum working shift for new doctors will be reduced from 24 hours to 16 hours, but the 80-hour weekly working limit will remain in effect. The Council is encouraging strategic napping. The Council has also decided that residents must tell patients that they're being supervised by more experienced doctors.

More at MSNBC | Posted 7 years ago by Peggy Rowland

Tags: Accreditation Council for Graduate Medical Education, Rookie Doctors, New Rules for Doctor Working Hours, New Physicians, New Physician Rules, Maximum Working Shifts

Comment on This | Was this Interesting? Yes! (51%) / No! (49%)

Small Molecules Make Big Impact

3 Group of Genes Disables Important Tumor Suppressor

Scientists in Australia and America have shown that a class of genes called “microRNAs” made by parts of the genome interfere with p53, the major tumor suppressor gene that is disabled or mutated in many cancers. They chose to study neuroblastoma, a cancer of the nervous system in children that often does not involved mutated p53. They found that cancer cells over-produce microRNA380, disabling p53. Genes make RNA, which codes for proteins that do the work in a cell. MicroRNA380 appears to bind to the RNA and inhibit p53 protein production, decreasing levels of p53 protein and allowing tumors to grow. Inhibiting microRNA380 restarted p53 protein production and tumors shrank as cancer cells died. This discovery will likely provide new ways of developing treatments for other cancers.

More at Science Daily | Posted 7 years ago by Kristie Hayes

Previously: New Drug Safe in Kids with Brain Tumors

Tags: P53, Tumor Suppressor Gene, MicroRNAs, MicroRNA380, Neuroblastoma

Comment on This | Was this Interesting? Yes! (51%) / No! (49%)

Drugs First, Then Lumpectomy

4 Shrink Breast Tumors for Less Dramatic Surgery

A new study suggests that treating women who have estrogen-fueled breast cancer with hormone- blocking pills to shrink the tumors allow them to have a lumpectomy instead a mastectomy in which the whole breast is removed. This study looked at 374 women who had tumors that were very sensitive to estrogen. They gave them one of three hormone-blocking drugs: Arimidex, Femara or Aromasin. At four months 71 percent, 67 percent and 61 percent of women on Femara, Arimidex and Aromasin, respectively, saw their tumors shrink by at least 50 percent. Fifty percent of women who were initially told they had to have mastectomies received lumpectomies as did about 82 percent considered marginal candidates for the breast-conserving surgery. A second study will determine which drugs are most effective.

More at Yahoo! AP | Posted 7 years ago by Kristie Hayes

Previously: Georgia Woman Loses Breast to Spider Bite

Tags: Breast Cancer, Mastectomy, Lumpectomy, Estrogen-Fueled Breast Cancer, Arimidex, Femara, Aromasin

Comment on This | Was this Interesting? Yes! (46%) / No! (54%)

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