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Not Only Due to Estrogen Loss

Reasons for Postpartum Depression Explained

Up to 70 percent of new mothers experience symptoms of depression within the first week after giving birth. While, the symptoms dissipate in most cases, up to 13 percent of women experience clinical level postpartum depression (PPD). Fluctuations in estrogen have been to blame but now new research reveals that, while estrogen levels drop 100 to 1000 fold after giving birth, levels of the enzyme monoamine oxidase A (MAO-A) increase dramatically throughout the brain. MAO-A is responsible for breaking down neurotransmitters serotonin, dopamine, and norepinephrine, and, ultimately, for controlling our moods. By balancing MAO-A, this research “could have an impact on prevention and treatment of postpartum depression in the future", says lead author Julia Sacher.

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